Category Archives: weight – loss

THE NEW AND IMPROVED HOLY GRAIL OF WEIGHT-LOSS, OH MY, IT’S THE ‘THUNDER GOD VINE’! VOL. 1 NO. 31


An extract from the peeled root of the thunder god vine, Tripterygium wilfordii, used in traditional Chinese medicine, lowers food intake and causes up to a 45% decrease in body weight in obese mice. The active weight-loss compound is called Celastrol. Its potent mechanism of action sensitizes cells to an appetite-suppressing hormone called leptin. The research, entitled “Treatment of Obesity with Celastrol” published in “Cell,” is an indicator that a purified Celastrol compound could be developed into a drug for obesity.

Umut Ozcan
Umut Ozcan

Senior researcher Umut Ozcan, an endocrinologist at Boston children’s Hospital and Harvard Medical School states, “During the last two decades, there has been an enormous amount of effort to treat obesity by breaking down leptin resistance, but these efforts have failed. The message from this study is that there is still hope for making leptin work, and there is still hope for treating obesity. If Celastrol works in humans as it does in mice, it could be a powerful way to treat obesity and improve the health of many patients suffering from obesity and associated complications, such as heart disease, fatty liver, and type 2 diabetes.”

Click to enlarge
Click to enlarge

Leptin, a fat cell derived hormone, tells the brain that the body has enough food. Mice and people that lack leptin signaling eat huge quantities and become morbidly obese. Leptin does not reduce hunger or food intake in the obese regardless of high levels of leptin in the bloodstream.

Ozcan et al. found that Celastrol improved cell sensitivity to leptin in human cells. Obese mice reduced food intake approximately 80% compared to untreated obese mice. After three weeks of treatment, the mice lost 45% of their body weight by burning fat stores.

This impressive weight-loss exceeds the weight-loss produced by bariatric surgery. In addition, Celastrol lowered cholesterol levels and improved liver function and glucose metabolism. This translates into a lower risk for heart disease, fatty liver, and type 2 diabetes.

ChineseMedicine_web_1024“Even though Celastrol did not produce toxic effects in mice, Ozcan strongly urges caution for now because in-depth toxicology studies and controlled clinical trials are needed to demonstrate the compound’s safety in humans. “ Celastrol is found in the roots of the thunder god vine in small amounts, but the plant’s roots and flowers have many other compounds,” he says. “As a result, it could be dangerous for humans to consume thunder god vine extracts to lose weight.””

In future research, Ozcan et al. will investigate Celastrol at the molecular level. Moreover, how it improves leptin sensitivity producing weight-loss. “We have been heavily focusing on this line of research in my laboratory and hope that this approach will help us to understand the mechanisms in nature that are leading to the development of obesity,” Ozcan says. “In the end, my main goal is to see this research leading to a novel and powerful treatment for obesity in humans.”

Dear readers, if you have read this far, the Captain would be most heartened if you would rate this and future articles and/or leave a comment at the top of the blog posts whether positive or negative. In this way, “The Fat Bastard Gazette” may better serve you and our entire readership.


Cell, Liu et al. “Treatment of Obesity with Celastrol

DOI:10.1016/j.cell.2015.05.011

Cell Press

Press, C. (2015, May 22). “Thunder god vine used in traditional Chinese medicine is a potential obesity treatment.” Medical News Today. Retrieved from
http://www.medicalnewstoday.com/releases/294295.php.

 

 

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot  Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.

WHAT HAPPENS TO ALL THAT FAT WHEN YOU LOSE WEIGHT?


 

_origin_Atomieroci-NEVAR-2According to an article in “The British Journal of Medicine,” it is time to blow the lid off the confusion and misconceptions about how we lose weight. Most individuals believe that fat is changed into energy or heat thereby losing weight. This goes against the law of conservation of mass. Other misconceptions are that substances produced from fat are excreted in kaka duty or changed into muscle. It is time for a little refresher course or introduction to Anatomy and Physiology /Biochemistry.

 

bigstock-Fat-woman-eating-a-hamburger-12163661Excess carbohydrate or protein is converted to triglyceride (glycerol ester) and stored in lipid droplets (fat globules) of adipocytes (fat cells). The excess fat from diet needs no conversion other than lipolysis of fats into fatty acids and glycerol, as by lipase (an enzyme excreted by the pancreas) and re- esterification. “People who wish to lose weight while maintaining their fat-free mass is, biochemically speaking, attempting to metabolise the triglycerides stored in their adipocytes.”

 

  • Lipid is any of a group of organic compounds that are greasy to the touch, insoluble in water, and soluble in alcohol and ether: lipids comprise the fats and other esters with analogous properties and constitute, with proteins and carbohydrates, the chief structural components of living cells.
  • Ester is a compound produced by the reaction between an acid and an alcohol with elimination of a molecule of water.
  • Fatty acid is any of a large group of organic acids, especially those found in animal and vegetable fats and oils. Fatty acids are mainly composed of long chains of hydrocarbons ending in a carboxyl group. A fatty acid is saturated when the bonds between carbon atoms are all single bonds. It is unsaturated when any of these bonds is a double bond.
  • Glycerol (an alcohol) is a sweet, syrupy liquid obtained from animal fats and oils or by the fermentation of glucose.
  • Triglyceride is and ester obtained from glycerol by the esterification of three hydroxyl groups with fatty acids, naturally occurring in animal and vegetable tissues: an important energy source for much of the fat stored by the body.
  • Lipolysis is the hydrolysis (chemical decomposition in which a compound is split into other compounds by reacting with water) of fats into fatty acids and glycerol, as by lipase (excreted by the pancreas).

 

Therefore, we can roughly scratch out a formula in English that describes where the average triglycerides in fat go in an exothermic reaction:

Triglycerides + Oxygen  —> Carbon Dioxide + Water + Energy.

 

The equation shows the metabolic results of fat oxidation, but leaves us in a quandary about their proportion of mass that leave as carbon dioxide and water during ones weight-loss. This is important because of what was stated earlier about the conservation of mass!

 

exhaled weight loss
When somebody loses 10 kg of fat (triglyceride), 8.4 kg is exhaled as CO2. The remainder of the 28 kg total of CO2 produced is contributed by inhaled oxygen. Lungs are therefore the primary excretory organ for weight loss. (This calculation ignores fat that may be excreted as ketone bodies under particular (patho)physiological conditions or minor amounts of lean body mass, the nitrogen in which may be excreted as urea)

 

Simply put after all the molecular weight computations are completed, it shows that 84% of the triglyceride molecules’ mass exhaled is carbon dioxide. 16% of mass becomes water.

The results clearly show that the lungs are the primary excretory organ for weight-loss. The water made may be excreted in the pee pee, pooh pooh, sweat, breath, tears or other fluids.

So fellow travelers, we are about to dispel the mystery on weight-loss with an example provided by the bmj. “At rest, an average 70 kg (154 lb.) person consuming a mixed diet exhales about 200 ml (7 oz.) of CO2 in 12 breaths per minute. Each of those breaths therefore excretes 33 mg (1 oz.) of CO2, of which 8.9 mg (.00032 oz.) is carbon. In a day spent asleep, at rest, and performing light activities that double the resting metabolic rate, each for 8 hours, this person exhales 0.74 kg of CO2 so that 203 g (7 oz.) of carbon are lost from the body. For comparison, 500 g (18 oz.) of sucrose (C12H22O11) provides 8400 kJ (2000 kcal) and contains 210 g (7 oz.) of carbon. Replacing one hour of rest with exercise that raises the metabolic rate to seven times that of resting by, for example, jogging, removes an additional 39 g (1.4 oz.) of carbon from the body, raising the total by about 20% to 240 g (8.5 oz.). For comparison, a single 100 g (3.5 oz.) muffin represents about 20% of an average person’s total daily energy requirement. Physical activity as a weight loss strategy is, therefore, easily foiled by relatively small quantities of excess food.

Our calculations show that the lungs are the primary excretory organ for fat. Losing weight requires unlocking the carbon stored in fat cells, thus reinforcing that often heard refrain of “eat less, move more.””

 

Once again, we are confronted with the fact that gaining weight is much easier than losing weight. The body wants to be in a state of homeostasis (balance) and works hard to conserve energy. Exercise is only 20% of the equation the remaining 80% is diet. The question remains, why we insist on stuffing ourselves when the consequences are so dire to health and take so much effort to undo.

 


 

The American Heritage® Science Dictionary. Retrieved May 11, 2015, from Dictionary.com website:http://dictionary.reference.com/browse

BMJ 2014; 349 doi: http://dx.doi.org/10.1136/bmj.g7257 (Published 16 December 2014)

 

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot  Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.