VITAMIN C IS THE NEW GREAT HOPE FOR SLUGABEDS AND LAYABOUTS! VOL.1 NO. 70


Endo dysfunction Click to enlarge
Endo dysfunction Click to enlarge

Recent studies show that greater than 50% of overweight and obese adults do not exercise. This fact contributes to elevated endothelin (ET)-1[1], a protein, causing vasomotor dysfunction[2] [3]vasoconstriction, and increased vascular risk[4]. Regular aerobic exercise is a lifestyle strategy that reduces ET-1 mediated[5] vasoconstrictor [6] tone.

Caitlin Dow, Ph.D. Postdoctoral Research Fellow in the Integrative Vascular Biology Laboratory Boulder, Colorado Research
Caitlin Dow, Ph.D.
Postdoctoral Research Fellow in the Integrative Vascular Biology Laboratory
Boulder, Colorado Research

Since regular aerobic exercise is not a part of the sedentary lifestyle followed by most adults, researchers led by Caitlin Dow Ph.D., postdoctoral research fellow at the University of Colorado, Boulder, examined whether or not vitamin C is as beneficial to vascular health as aerobic exercise in lowering ET-1 system activity in overweight and obese adults. It is already known that vitamin C positively influences endothelial function.

Chair SleepingThe study included 35 sedentary, overweight, and obese adults. Of these, 20 individuals were selected to complete three months of a vitamin C (500 mg/day, timed-release) regimen; the other 15 individuals completed aerobic (walking) exercise training. Forearm blood flow measurements were taken before and after the two interventions. The researchers found vitamin C is as effective as walking in reducing ET-1 related arterial vessel constriction. Therefore, a vitamin C regimen is effective as a lifestyle strategy for reducing ET-1 mediated vasoconstriction

Dear readers, if you have read this far, the Captain would be most heartened if you would rate this and future articles and/or leave a comment at the top of the blog posts whether positive or negative. In this way, “The Fat Bastard Gazette” may better serve you and our entire readership.

 

Vitamin C: The Exercise Replacement? (2015, September 2). Retrieved September 9, 2015, from Newswise: http://www.newswise.com/articles/vitamin-c-the-exercise-replacement

 


 

[1] The endothelium regulates local vascular tone and integrity through the coordinated release of vasoactive molecules. Secretion of endothelin-1 (ET-1) from the endothelium signals vasoconstriction and influences local cellular growth and survival. ET-1 has been implicated in the development and progression of vascular disorders such as atherosclerosis and hypertension.

[2] affecting diameter of blood vessels causing or influencing changes in the diameter of blood vessels in an inappropriate way

[3] Myocardial ischemia is known to be precipitated by a mismatch between oxygen demand and supply secondary to epicardial coronary artery stenosis (i.e. constriction.) The tendency for developing myocardial ischemia is greater in those with more severe obstructive epicardial CAD (coronary artery disease) and with microvascular dysfunction manifested as abnormal vasodilatory and vasoconstrictor function of the peripheral circulation.

[4] Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of arteriosclerosis in which an artery wall thickens as a result of invasion and accumulation of white blood cells (WBCs)(foam cell) and proliferation of intimal smooth muscle cell creating a fibro-fatty plaque.

[5] to act as a medium that transfers something from one place to another in the body

[6] causing narrowing of the blood vessels

 

 

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner, and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity.

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.

 

 

 

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s