WHAT EFFECT DOES MARY JANE REALLY HAVE ON WEIGHT GAIN? Vol. 1 No. 48


Didier Jutras-Aswad, University of Montreal professor and researcher at the CHUM Research Centre.
Didier Jutras-Aswad, University of Montreal professor and researcher at the CHUM Research Centre.

“While cannabis alters the functions of neurobiological circuits controlling appetite, its effect on weight gain is complex since several factors appear to be involved,” says Didier Jutras-Aswad. “It is known – and often reported by users – that cannabis causes temporary increase in appetite. As to whether it actually causes weight gain in the long term, the available data is limited. The question is all the more difficult to answer since many other factors can influence weight. For instance, cannabis use may be associated with cigarette smoking, which also alters appetite, and many effects of cannabis vary by gender and level of use. For this study, we wanted to better understand the association between cannabis and weight gain by paying particular attention to these factors. The main finding of our study shows that long-term cannabis use indeed influences weight gain. But above all, we noted that certain factors drastically modify this effect, including gender, level of use, and concomitant cigarette smoking.”

So this is why they call it DOPE.

“ What was surprising in this study was the complexity of interacting factors,” said Dr. Jutras-Aswad. “We were able to group participants according to various levels of use to conduct our analyses. Specifically, in male non-cigarette smokers, greater cannabis use led to greater weight gain. And significantly, in male cigarette smokers, the effect was almost the opposite.”

19057145 Dr. Jutras-Aswad et al. based their conclusions using data from the Nicotine Dependence in Teens (NDIT) study, led by Jennifer O’Loughlin. Starting at the age of 12 or 13, 1,294 young people agree to give information yearly about their diet, mental and physical health, physical activities, frequency, and levels of their cannabis, alcohol, and/or nicotine use. Due to the detailed nature of the study, researchers were able to rule out other weight factors that could influence weight gain in their study. (Raillant-Clark, 2015) “The effects of these substances observed in highly controlled laboratory settings are more complex than anticipated in real-world settings,” explained Jutras-Aswad. “The NDIT study provided us with the opportunity to have detailed longitudinal data to better respond to a research question requiring consideration of several factors simultaneously.”

New Year Celebration
Livin’ the glamorous and exotic high life!

For the time being, Dr. Jutras-Aswad et al. are unable to explain the difference between men and women, but they have some hypotheses. “ THC and nicotine do not affect the neurobiological circuits controlling hunger in the same way in men and women,” explained Jutras-Aswad. “We also know that these targets in the brain are modified by hormonal factors that can fluctuate, in particular, during menstrual cycles. There are also possible psychological differences in men and women in their perception of and preoccupation with weight gain and diet, which could hypothetically explain why men seem specifically sensitive to the complex interaction between cannabis use, cigarette smoking, and weight gain.”

 http://www.healthline.com/health/addiction/marijuana/effects-on-body

791676441-1024x682
We’re cool, we’re cool…

Finally, the study equips scientists and health practitioners in improving knowledge and combating cigarette smoking, cannabis abuse, and obesity (Raillant-Clark, 2015) “One of the great strengths of our study is that it is highly instructive about how to study the effects of cannabis use on weight gain, but also the risk of developing other health problems. Our data indicate that concomitant cigarette smoking and gender must also be taken into account in the individuals concerned,” said Jutras-Aswad. “Regarding interventions with the population, one of the findings to keep in mind is that when a person uses cannabis they also often report using tobacco. When one substance is used, another one is often consumed. We must therefore be able to prevent, detect, and intervene in the problematic use of several substances simultaneously,” stated Dr. Jutras-Awad.

Dear readers, if you have read this far, the Captain would be most heartened if you would rate this and future articles and/or leave a comment at the top of the blog posts whether positive or negative. In this way, “The Fat Bastard Gazette” may better serve you and our entire readership.


 

About the study:
Emily Dubé, Jennifer O’Loughlin, Igor Karp, and Didier Jutras-Aswad published “Cigarette smoking may modify the association between cannabis use and adiposity in males” in Pharmacology Biochemistry and Behavior on May 27, 2015. The NDIT study was funded by the Canadian Cancer Society. Doctor Jutras-Aswad is affiliated with the Université de Montréal’s Department of Psychiatry and the Université de Montréal Hospital Research Centre. He holds a clinical research career award from the Fonds de recherché du Québec – Santé.

Raillant-Clark, W. (2015, June 30). WHAT EFFECT DOES MARIJUANA REALLY HAVE ON WEIGHT GAIN? Retrieved June 30, 2015, from CRCHUM: http://crchum.chumontreal.qc.ca/en/what-effect-does-marijuana-really-have-weight-gain

 

 

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.

 

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YOUR BRAIN ON FRIED EGGS VOL. 1 NO. 47


fulton_stephanie-500_0
Stephanie Fulton

“High-fat feeding can cause impairments in the functioning of the mesolimbic dopamine system,” says Stephanie Fulton of the University of Montreal and the CHUM Research Centre (CRCHUM). This system is a critical brain pathway controlling motivation.

Fulton’s research, published in Neuropsychopharmacology, may have great significance. “Our research shows that independent of weight gain and obesity, high-fat feeding can cause impairments in the functioning of the brain circuitry profoundly implicated in mood disorders, drug addiction, and overeating – several states and pathologies that impinge on motivation and hedonia,” Fulton explained. Hedonia relates to a mental state of wellbeing. “Another key finding is that the effects of prolonged high-fat feeding to dampen the sensitivity of this brain reward system are specific to saturated fats – palm oil used in this study – but not monounsaturated fat such as the olive oil used in this study.”

Ricoh Company Ltd.
Ricoh Company Ltd.

Researchers derived these findings by working with three groups of rats. The first group of rats was the control group: these rats were given a low fat diet containing equal amounts of monounsaturated and saturated fatty acids. The second group of rats was given a monounsaturated high fat diet, of which 50% of the calories were from fat derived  from oil. The third group was given a saturated high fat diet of which 50% of the calories were from fat, but this time the fat was derived from palm oil. The high fat diets were equal in terms of sugars, proteins, fat content, and caloric density; the amount eaten by the rats was not controlled. At the end of the eight weeks, all of the rats had comparable body weights and levels of insulin, leptin (a major metabolic hormone) and glycemia.

Fat-People-Eating-Pictures-14-570x499During this time, the rats underwent a series of behavioral and biochemical tests known to be indicators of the functioning of the rats’ dopamine system. “We established that the rats on the palm diet had a significantly blunted dopamine function,” said Cecile Hryhorczuk, the first author of the study. “Our research group and others hypothesize that this leads the brain to try to compensate by heightening reward-seeking behavior, much like the phenomenon of drug tolerance where one has to increase the drug dose over time to get the same high. So, a person consuming too much saturated fat may then compensate a reduced reward experience by seeking out and consuming more high-fat and high-sugar foods to get the same level of pleasure or reward.”

Fulton et al.’s research is a first of its kind to point out, regardless of weight changes, unrestricted intake of saturated fats can have negative effects on the controls of motivation by the brain. “As we were able to control for changes in body weight, hormones, and glucose levels, we think that the fats may be affecting the dopamine system by a direct action in the brain,” Fulton said. “We in fact have separate evidence that brain inflammation could be involved in this process, as it is evoked by saturated high-fat feeding, which will be presented in a future publication.”


About this study:

Stephanie Fulton and her colleagues published, “Dampened mesolimbic dopamine function and signaling by saturated but not monounsaturated dietary lipids” in Neuropsychopharmacology on July 14, 2015. Stephanie Fulton, PhD, is a professor at the University of Montreal’s Department of Nutrition while Cecile Hryhorczuk, MSc, is affiliated with the university’s Department of Physiology. Both are researchers at the Montreal Diabetes Centre and the CHUM Research Centre (CRCHUM.)

This research was supported by funding from the Canadian Institutes for Health Research (MOP123280, MOP115042, MOP9575), the Fonds de Recherché Quebec-Santé, the National Science and Engineering Research Council (249848-2007 RGPIN), the Montreal Diabetes Research Center/Université de Montréal and CMDO/Novo Nordisk.

The University of Montreal is officially known as Université de Montréal.

University of Montreal

MNT. (2015, JULY 15). Retrieved from THIS IS YOUR BRAIN ON FRIED EGGS: http://www.medicalnewstoday.com/releases/296784.php.

Raillant-Clark, W. (2015, July 14). THIS IS YOUR BRAIN ON FRIED EGGS. Retrieved July 19, 2015, from CRCHUM: http://crchum.chumontreal.qc.ca/en/news-briefs/your-brain-fried-eggs

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.

Dust, Cattle Feed Yards, Antibiotic Resistance VOL. 1 No. 46


Cattle at the trough eating antibiotics enriched grain.
Cattle at the trough eating antibiotics enriched grain.

More antibiotics and antibiotic resistant pathogens released into the air we breathe. The culprit, cattle in cattle feed yards fed antibiotics enriched cattle feed. Route of transmission, dried cattle urine, and feces scattered by the wind as tiny particulate matter (i. e. dirt and dust) according to Environmental Health Perspectives, “Dust Emissions from Cattle Feed Yards: A Source of Antibiotic Resistance?.”

resistant e. coli
resistant e. coli

The cattle do not digest approximately 80% of the antibiotics consumed. These undigested antibiotics along with their partially digested metabolites and antibiotic resistant pathogens via dried cattle urine and feces, potentially harmful to humans, spread across the land via runoff from rain, as manure, and wind. “There is evidence that, once in the environment, antibiotics and antibiotic-resistance genes in bacteria may facilitate new antibiotic resistance or directly transfer genetic resistance to other microbial populations.” 1

What is just as troubling is the fact that cattle are fed antibiotics not only to prevent disease but also to increase weight by as much as 20 pounds. Is this a healthy weight gain or just bloat? Not to mention the fact that we are ingesting these antibiotics the cattle absorb.

image of Streptococcus which can be found in animals and humans.
image of Streptococcus which can be found in animals and humans.

The three classes of antibiotics in question are monensin, tylosin, and the tetracycline antibiotics. Monensin is the only antibiotic of the three not approved for human consumption. It is shown that monensin does not confer “resistance against medically important classes of antibiotics.” 1 But what about tylosin and the broad-spectrum antibiotic tetracycline which is inexpensive, readily available, and effective against many bacterial diseases? This is something to consider! The half-life of tetracycline is approximately 30 to 180 days, more than enough time to increase and multiply tetracycline resistant bacteria. Not to mention the fact that these resistant strains are carried around the world given the right weather patterns.

cattle-grazing-377p-orig-istockWhat is to be done? For starters, reduce the number of gargantuan cattle feedlots. Big agribusiness and the very politic of their Washington lackeys certainly will not do this though. Stop feeding cattle antibiotics enriched corn and soy. Go back to range feeding of cattle. We can all do with a little less beef if it means producing a better and more healthful product.

Dear readers, if you have read this far, the Captain would be most heartened if you would rate this and future articles and/or leave a comment at the top of the blog posts whether positive or negative. In this way, “The Fat Bastard Gazette” may better serve you and our entire readership.


 

  1. (Seltenrich, 2015)

Click here to see entire article  http://ehp.niehs.nih.gov/123-a96/

 

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot  Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.

 

 

SOME BENEFITS OF A VEGAN DIET VOL. 1 NO. 45


Low fat plant based diets have been shown to improve glycemic control, blood lipid concentrations, blood pressure and weight. Diet acceptance is similar to that of other diets.

Researchers, N D Barnard et al. 1, conducted a 20-week low fat plant based diet intervention measuring any benefits of a Vegan diet vs. a control group given a B12 vitamin pill as a placebo control. Body weight and BMI (body mass index) showed a greater decrease in intervention group, and blood sugar greatly declined in the intervention group only. The researchers also observed a decrease in the effects of neuropathy in type 2 diabetics as well as the control group. The intervention group reported less pain caused by neuropathy when given various pain questionnaires. The control group also reported improvements in self-reported pain.

studies-show-vegan-diets-are-lacking-in-saturated-animal-fat-cholesterol-carcinogens-violence-suffering-and-deathBernard et al. 1 conducting this pilot intervention found similar results with other smaller studies that were focused on improvements in neuropathic pain and symptoms with the dietary intervention. A study by Crane and Sample2 used a reduced calorie, low fat, plant based diet with exercise for 25 days. 81% of participants in the study reported complete remission of symptoms. The remaining participants reported partial amelioration of their symptoms. Other noted changes included weight-loss decreased blood lipid concentrations and reduced need for blood pressure meds and glucose control meds.

PAMpartsPETA300
PAMpartsPETA300

Susan E. Berkow, PhD, CNS, and Neal Barnard, MD concluded in an earlier study, “Observational studies indicate that the weight and BMI of both male and female vegetarians, on average, is approximately 3% to 20% lower than that of non-vegetarians. Obesity prevalence ranges from 0% to 6% in vegetarians and from about 5% to 45% in non-vegetarians. Randomized trials suggest that dietary factors influencing energy intake and possibly thermic effect of food may be responsible for these differences. Because vegetarian diets are associated with reduced body weight and lower rates of obesity, vegetarians generally have a lower risk of coronary heart disease, hypertension, and diabetes. A 1995 study estimated that vegetarians also incur significantly lower medical costs compared with non-vegetarians. The positive effects of a plant-based diet on chronic disease prevention may be mediated, in part, by changes in body weight.”5

In another study, Smith et al.3 investigated individuals with impaired glucose tolerance and peripheral neuropathy. Participants were coached on a diet and exercise in this one-year study. Smith et al. found participants had greater glucose tolerance, decreased body weight, and decrease cholesterol levels. Insignificant improvements in pain were reported. Bernard et al.’s study was more intense but of a shorter duration.

Vegan food pyramid Click to enlarge

The mechanisms of action by which the Vegan diet improves neuropathic pain “may involve improved insulin sensitivity, leading to better glucose control. 4 in addition, diabetic neuropathy is associated with hypertension, dyslipidemia, and obesity, all of which can be ameliorated with the plant-based diet.” 56, 7 

 Bernard et al. state that this pilot study shows the potential for a dietary approach in treating diabetic neuropathy as well as weight gain.

The researchers went on to say that, nutrition studies are important “given that drugs used to manage blood glucose have significant side effects, and drugs used for diabetic nerve pain typically offer only limited benefit. Further studies might eliminate the confounding factor of vitamin B12 status by including vitamin B12 pretreatment or an alternative control, such as a subclinical dose of B12. A trial testing diet, exercise and vitamin B12 in combination might be a useful means of assessing the effects of a more intensive intervention in this otherwise intractable and debilitating chronic disease.” 1

Dear readers, if you have read this far, the Captain would be most heartened if you would rate this and future articles and/or leave a comment at the top of the blog posts whether positive or negative. In this way, “The Fat Bastard Gazette” may better serve you and our entire readership.


 

  1.  A E Bunner, C. L. (2015, 5 26). A dietary intervention for chronic diabetic neuropathy pain: a randomized controlled pilot study. Retrieved 6, 2, 2015, from Nutrition & Diabetes: http://www.nature.com/nutd/journal/v5/n5/full/nutd20158a.html
  2. Crane MG, Sample C. Regression of diabetic neuropathy with total vegetarian (vegan) diet. J Nutr Med1994; 4: 431–439. | Article |
  3. Smith AG, Russell J, Feldman EL, Goldstein J, Peltier A, Smith S et al. Lifestyle intervention for pre-diabetic neuropathy. Diabetes Care2006; 29: 1294–1299. | Article | PubMed | ISI |
  4. Barnard ND, Scialli AR, Turner-McGrievy G, Lanou AJ, Glass J. The effects of a low fat, plant-based dietary intervention on body weight, metabolism, and insulin sensitivity. Am J Med2005; 118: 991–997. | Article | PubMed | ISI | CAS |
  5. Berkow SE, Barnard N. Vegetarian diets and weight status. Nutr Rev2006; 64: 175–188. | Article | PubMed | ISI |
  6. Barnard N, Akhtar A, Nicholson A. Factors that facilitate dietary change. Arch Fam Med1995; 4: 153–158. | Article | PubMed | CAS |
  7. Yokoyama Y, Nishimura K, Barnard ND, Takegami M, Watanabe M, Sekikawa A et al. Vegetarian diets and blood pressure: a meta-analysis. JAMA Intern Med2014; 174: 577–587. | Article | PubMed | ISI |

 

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot  Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.