THE NEW AND IMPROVED HOLY GRAIL OF WEIGHT-LOSS, OH MY, IT’S THE ‘THUNDER GOD VINE’! VOL. 1 NO. 31


An extract from the peeled root of the thunder god vine, Tripterygium wilfordii, used in traditional Chinese medicine, lowers food intake and causes up to a 45% decrease in body weight in obese mice. The active weight-loss compound is called Celastrol. Its potent mechanism of action sensitizes cells to an appetite-suppressing hormone called leptin. The research, entitled “Treatment of Obesity with Celastrol” published in “Cell,” is an indicator that a purified Celastrol compound could be developed into a drug for obesity.

Umut Ozcan
Umut Ozcan

Senior researcher Umut Ozcan, an endocrinologist at Boston children’s Hospital and Harvard Medical School states, “During the last two decades, there has been an enormous amount of effort to treat obesity by breaking down leptin resistance, but these efforts have failed. The message from this study is that there is still hope for making leptin work, and there is still hope for treating obesity. If Celastrol works in humans as it does in mice, it could be a powerful way to treat obesity and improve the health of many patients suffering from obesity and associated complications, such as heart disease, fatty liver, and type 2 diabetes.”

Click to enlarge
Click to enlarge

Leptin, a fat cell derived hormone, tells the brain that the body has enough food. Mice and people that lack leptin signaling eat huge quantities and become morbidly obese. Leptin does not reduce hunger or food intake in the obese regardless of high levels of leptin in the bloodstream.

Ozcan et al. found that Celastrol improved cell sensitivity to leptin in human cells. Obese mice reduced food intake approximately 80% compared to untreated obese mice. After three weeks of treatment, the mice lost 45% of their body weight by burning fat stores.

This impressive weight-loss exceeds the weight-loss produced by bariatric surgery. In addition, Celastrol lowered cholesterol levels and improved liver function and glucose metabolism. This translates into a lower risk for heart disease, fatty liver, and type 2 diabetes.

ChineseMedicine_web_1024“Even though Celastrol did not produce toxic effects in mice, Ozcan strongly urges caution for now because in-depth toxicology studies and controlled clinical trials are needed to demonstrate the compound’s safety in humans. “ Celastrol is found in the roots of the thunder god vine in small amounts, but the plant’s roots and flowers have many other compounds,” he says. “As a result, it could be dangerous for humans to consume thunder god vine extracts to lose weight.””

In future research, Ozcan et al. will investigate Celastrol at the molecular level. Moreover, how it improves leptin sensitivity producing weight-loss. “We have been heavily focusing on this line of research in my laboratory and hope that this approach will help us to understand the mechanisms in nature that are leading to the development of obesity,” Ozcan says. “In the end, my main goal is to see this research leading to a novel and powerful treatment for obesity in humans.”

Dear readers, if you have read this far, the Captain would be most heartened if you would rate this and future articles and/or leave a comment at the top of the blog posts whether positive or negative. In this way, “The Fat Bastard Gazette” may better serve you and our entire readership.


Cell, Liu et al. “Treatment of Obesity with Celastrol

DOI:10.1016/j.cell.2015.05.011

Cell Press

Press, C. (2015, May 22). “Thunder god vine used in traditional Chinese medicine is a potential obesity treatment.” Medical News Today. Retrieved from
http://www.medicalnewstoday.com/releases/294295.php.

 

 

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot  Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s