PREBIOTIC FIBER, RATS, HUMANS, AND WEIGHT-LOSS VOL. 1 NO. 36


labratsA research team from the University of Calgary’s Cumming School of Medicine and the Faculty of Kinesiology found that rats on a high fat, high sugar diet had a much lower weight gain than the ones who did not eat the fiber.

“Our data shows that a simple dietary intervention, with a prebiotic oligofructose fiber, reduced weight gain, and this may also lead to the long-term maintenance of a lower body weight in the face of continued dietary challenge,” says Keith Sharkey, PhD, senior author of the study and deputy director of the Cumming School of Medicine’s Hotchkiss Brain Institute (HBI).”

Fat-Lab-Rats-Unsuitable-for-Research-2Nina Cluny, PhD, a postdoctoral fellow in the HBI and the Department of Physiology and Pharmacology stated that weight-loss and maintenance showed similar results regardless of the rats predisposition to obesity.

Oligofructose is a dietary fiber founded in vegetables like onions and bananas. A prebiotic fiber supplies food for the bacteria that lives in our intestines.

intestinal_bacteria“Trillions of bacteria live in the human gut, collectively forming what is known as our microbiota. They help with everything from digesting food to warding off harmful micro-organisms. Oligofructose is suspected to decrease weight gain by affecting the composition of microbiota and some of the gut hormones that control food intake.”

In a 2009 human study raylene Reimer, Ph.D., R.D. and a professor in the faculty of kinesiology found that adults receiving doses of oligofructose lost an average of 2.2 pounds over a 12-week period. Most importantly, a gain continued to gain weight like the group who took the placebo (i. e. sugar pill).

oligofructose“Oligofructose  shouldn’t be seen as a potential alternative to exercise and diet, which have many other health benefits besides lowering weight, says Sharkey. He, Cluny and Reimer instead view the fiber as one of many possible tools in the fight against the growing problem of obesity.”

Dear readers, if you have read this far, the Captain would be most heartened if you would rate this and future articles and/or leave a comment at the top of the blog posts whether positive or negative. In this way, “The Fat Bastard Gazette” may better serve you and our entire readership.


To read entire article click

http://medicalxpress.com/news/2015-04-rats-fed-dietary-fiber-supplement.html

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot  Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.

A BALANCED DIET AND EXERCISE WIN AGAIN! VOL. 1 NO. 35


FatTVSheeple550x440It is time once again to sound the clarion call to the benefits of diet and exercise.

As the decades march on, the body of scientific evidence grows. A good diet and physical activity are the cornerstones of health and disease prevention.

Americans are living large both figuratively and literally with most people preferring there 60 inch flat screen and a nice comfy couch to what science says is good for us.

Cheryl Anderson. Photo by Erik Jepsen/UC San Diego Publications
Cheryl Anderson. Photo by Erik Jepsen/UC San Diego Publications

According to the article “Recipe for Wellness” Cheryl Anderson, a member of the national 2015 Dietary Guidelines Advisory Committee, and other nutrition research specialists spent more than 18 months reviewing what is known about diet related disease prevention. In no uncertain terms, the committee, which meets every five years with the Federal government regarding nutrition policy and food assistance programs, called “for bold action and sound innovative solutions” to address the nation’s health problem.

fat_people_on_scooters_6The statistics are plain. Approximately 50% of all American adults—117 million people—have one or more preventable, chronic diseases related to poor nutritional habits and physical inactivity. The list includes heart disease, high blood pressure, colon cancer, and breast cancer.

More than two thirds of adults and nearly one third of children and adolescents are clinically overweight or obese.

The committee in its scientific report stated, “These devastating health problems have persisted for decades, strained U.S. health care costs and focused the attention of our health care system on disease treatment rather than prevention. Unfortunately, few improvements in consumers’ food choices have occurred in recent decades.”

OLYMPUS DIGITAL CAMERA
OLYMPUS DIGITAL CAMERA

So what is healthful nutrition that prevents diet related maladies? The research team found vegetables and fruits are a consistent part of the healthful dietary pattern. Vegetables and fruits were “consistently identified in every conclusion statement across health outcomes” as having strong signs for promoting health.” Less corroboration was also shown for nutritional patterns that include whole grains, low or nonfat dairy, seafood, beans and nuts.

More than any one diet, the committee stressed the ‘critical importance’ on an individual’s general eating tendencies and habits.

Anderson stated, “Our take-away message is that people need to shift their dietary patterns, control the size of food portions and decrease overall caloric intake. We want to move away from the idea that people should reduce intake of certain isolated foods and instead emphasize the idea of replacing some foods with more healthful options like fruits and vegetables.”

The committee of experts felt the media frequently alter or confuse the committee’s main message.

Anderson, an expert on nutrition and chronic disease prevention, stated, “The media often give the impression that nutritionists are saying ‘this food is good for you one week’ and then ‘that food is bad for you the next.’ It creates the impression that nutritional advice is always changing and that there is not a scientific consensus on what good nutrition is. That is not true.”

An example of this was the media brouhaha over the Dietary Guidelines Advisory Committee’s decision not to put specific limits on dietary cholesterol, creating headlines such as “Cholesterol is back on the menu in new federal dietary guidelines” or “Cholesterol in food not a concern, new report says.”

Anderson, a member of UC San Diego’s Cardiovascular Epidemiology and Prevention Center of Excellence and a fellow of the American Heart 918fd7f76824e9df55b51c7dc263a057Association, stated, “We did not set a recommended guideline on daily dietary cholesterol levels, as has been done in previous guidelines, because dietary cholesterol does not have an appreciable impact on serum cholesterol. Further, there was no evidence that cholesterol is a nutrient of concern for over or under consumption by the population. There is, however, scientific evidence showing that saturated fats do impact a person’s cardiovascular health. Our recommendation is that Americans get no more than 10 percent of their daily calories from saturated fat. That is not a green light to eat as many eggs as you want.”

“The lack of specific guidance on cholesterol was a subtle decision that recognizes a few nuanced foods, such as shrimp and shellfish, that are high in cholesterol but low in saturated fat, and can be part of a healthful diet,” Anderson explained. “To see the media focus on cholesterol in isolation of the report in its entirety was disheartening and was in direct contradiction to what the report focused on.”

In addition, the panel acknowledged for the first time the larger socioeconomic and sociocultural indicators that influence a person’s ability to eat well and exercise.

“Where a person lives, works, plays, and prays can facilitate or hinder a person’s ability to make healthy lifestyle choices,” Anderson said. “For example, we know there are ‘food deserts’ in America where people don’t have easy access to grocery stores.”

The committee noted that greater than 49 million people, including nearly 9 million children, living in food troubled households.

“She and the other committee members have urged the federal government to develop policies that foster a culture of health. These, Anderson said, might include making population health a national priority; ensuring resources for healthy lifestyles are accessible, affordable and normative for everyone; shifting health care and public health systems toward a greater emphasis on prevention; and enacting incentives to encourage environmental and policy changes, as well as better food and beverage standards and products.”

The federal government will develop new Dietary Guidelines for Americans based on information in the report, and from public comments and federal agency input.

Dear readers, if you have read this far, the Captain would be most heartened if you would rate this and future articles and/or leave a comment at the top of the blog posts whether positive or negative. In this way, “The Fat Bastard Gazette” may better serve you and our entire readership.


Johnson, C. (2015, May 14). Recipe for Wellness UC San Diego nutrition expert helps define national prescription for healthy diet. Retrieved May 15, 2015, from UC San Diego News Center: http://ucsdnews.ucsd.edu/feature/recipe_for_wellness

Scientific Report of the 2015 Dietary Guidelines Advisory Committee. (2015, February). Retrieved from health.gov: http://www.health.gov/dietaryguidelines/2015-scientific-report/

 

 

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot  Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.

 

EXTRA EDITION “ATTACK OF THE MORBIDLY OBESE DIVERSITY POLICE!” VOL. 1 NO. 34


2-13951-big-brother-orwellIn the prescient wisdom of “The Fat Bastard Gazette,” we declared as early as September 2, 2014 what should be done economically and punitively with unrepentant obese naves. Those far left rapscallions, who prowl about demanding accommodation from both private and public institutions, are making their mark more loudly and outrageously under the umbrella of cultural and personal diversity.

The Fat Bastard emphasizes the word unrepentant. We do not take umbrage with any individual who is morbidly obese and trying to overcome their condition. The Captain himself was 305 pounds, a class III morbidly obese individual. However, the cretins we do rail against are those strident cadres in the Fat Activist Movement and all their sympathetic followers.

fat-bastardThis is just another chink in the armor of Western Civilization, as we know it. It may be said ancient Rome fell not from without but from within. The barbarians were at the gate in just the right time to pick up the pieces. Therefore, so it is with the United States, the largest and presently strongest superpower since Rome, about to be decimated from within by, a pusillanimous group of Fat Activist provocateurs, and an ever widening, accepting, passive audience. We are in a state of decadent decline. The doors to the Scriptorium will be locked with only a select few holding the keys. Our moral fiber and personal accountability to the greater good are sinking at an ever-quickening rate into the moral morass of wanton hedonism.

As a disclaimer, the Captain wants fellow travelers to now that the use of the word fat, fat activist, and fat acceptance are terms used by the Journal of Gender Studies and not pejoratively used by “The Fat Bastard Gazette”

Research published in the Journal of Gender Studies suggest within the last few years, in Canada and the United States, blogs have become integral for fat women and their kindred spirits to create and further develop aggressive strategies to question feminine biased anti-fat conversations by media, government, medicine, and public health. Presently, popular conversations in regards to fat people, in particular women, tend to run from institutions implicating a good‘moral deficit’ to a ‘risky behavior’ to ‘political discrimination’ where parts from each conversation shape how fat women’s bodies are viewed within the larger culture. The main messages surrounding the ideal of the thin body center on good citizenship. These messages emphasize taking personal responsibility; encourage use strict diets and exercise, and “perpetuate an image of responsible citizenship” as an extension of these messages. Fat acceptance bloggers take elements from LGBTQ (Lesbian Gay Bisexual Trans Questioning) movements to extend aggressive dominating strategies, different forms of fat representation, and “address the economic marginalization of fat women in industry.” In addition, through conversations on beauty and body image, bloggers contest anti- fat themes to develop aggressive strategies beyond the themes of fat as a ‘lifestyle choice’, “and body size as biologically rich and genetically determined that dominate the fat acceptance movement.

bac7af26e4d59cdca5c5103e660a6389“For the contributors and founders of FaT GiRL, the world that fat women inhabit was made difficult to navigate through artificial barriers (e.g., small seats on buses); not fat bodies (Lebesco, 2004). The politics promoted by FaT GiRl diverge drastically from more conservative approaches to fat activism employed by groups like the NAAFA (National Association to Advance Fat Americans)   . PPPO’s (Pretty Porky and Pissed Off) performances, however, underline how public spaces can be and have been organized according to consumerist and fat phobic assumptions that circumscribe how fat women engage with them.”

82683a1c5750e0bd5f734ac7dc7afa5e“Visibility refers to how fat women may experience being fat in relation to anti-fat discourses and contest these discourses through visual strategies. Murray (2005) asserts that in the West, ‘we live in a culture of a negative collective “knowingness” of fat women‘ (p. 154), where fat women are ‘known’ to be lazy, lacking willpower, and (sexually) out of control. Such ‘knowledges’ are thought to ‘inform every interaction we have with others and the world, and position us along a spectrum of bodies and identities’ (p. 154). Murray (2005) asserts that current fat politics asks that the fat body be reconceived within dominant frameworks of beauty; demands sometimes superficially read as subversive.”

“Fat, then, remains popularly understood as an individual responsibility and moral failure and FA (Fat Activism) tantamount to celebrating bad behavior or poor lifestyle choices that lead or contribute to poor health outcomes (Rich & Evans, 2005; Saguy & Riley, 2005).”

“As a result, individual and collective bodies, as well as institutions, corporations, and states, must present as ‘lean,’ ‘fit,’ ‘flexible,’ and ‘autonomous’ to demonstrate power (Elliot, 2007; Lemke, 2001). The fat individual is then characterized as possessing none or limited amounts of those traits and, therefore, putting a strain on the ‘public’ (e.g., the perception that fat people drain government resources, increase medical insurance premiums, and literally take up more space in public areas). Not surprisingly, fat people are targeted by government interventions in an attempt to mitigate the ideological risk they present, which then leads to their further stigmatization (Elliot, 2007; Guthman & DuPuis, 2006; Lebesco, 2011).”

body-fat-percentage-men
Body-fat-percentage-men

“This stigmatization of fat bodies encourages the use of self-disciplinary practices (e.g., extreme dieting and exercise) to achieve a socially desired version of selfhood. The choices geared toward meeting the thin body ideal made by individuals exist within larger power structures maintained through ‘self-subjectification,’ defined as how individuals attempt to shape their bodies to meet, often unachievable, physical ideals (Connolly, 1985; Leahy, 2009). Meleo-Erwin (2011) suggests that individuals are ‘disciplined’ through self-subjectification in late capitalist society instead of through techniques of overt coercion; she argues that individuals are regulated through their active engagement with promoted practices and techniques that are normalized by self-subjective behaviors.”

“Implicit in body diversity discourses is the assumption that genetics determine the extent to which bodies regulate hunger and/or metabolize food at a weight-maintaining pace. This assumption has led FAs to assert people have a set weight point that their bodies will revert to without sustained or extreme dieting and exercise (Guthman & DuPuis, 2006; Saguy & Riley, 2005).”

Senator Joseph Mccarthy known for hunting down communists, McCarthy was the Chairman of the Government Operations Committee and its Permanent Subcommittee on Investigations of the U.S. Senate in the 1950s nicknamed
Senator Joseph Mccarthy known for hunting down communists, McCarthy was the Chairman of the Government Operations Committee and its Permanent Subcommittee on Investigations of the U.S. Senate in the 1950s nicknamed “Tailgunner Joe”

“Increasing knowledge of how self-identified women FA bloggers engage in FA politics and discourses online then, first, provides important insight into the way change or new phenomena in the FA movement in North America relates to the intersection of gender, race, and queer fat politics (Herdon, 2006). Second, this knowledge helps uncover the limitations of medicalized discourses around fat and fat embodiment, especially as it relates to women, by highlighting the ideological chasm that exists between medical and government institutions and fat acceptance activism and the cultural rather than the scientific assumptions that underpin them.”

night_club_for_overweight_01“As with earlier fat acceptance activists, such as the Toronto based group Pretty Porky and Pissed Off, bloggers, like Leslie Kinzel and Jennifer Rowe use or call strategies (e.g., political consumer activism) to highlight the factors that limit fat women’s participation in consumer culture, especially in the area of fashion. In calling for boycotts of retailers who refuse to sell clothing in larger and plus sizes, as Rowe has, fat people can draw attention to how they remain systemically underserved or ignored by certain industries.”

The extreme far left is on the march. Where is Tailgunner Joe when we need him?

Extraordinary taxes should be justly levied on all the truculent,strident, Fat Activists that put undue stress on health insurance premiums, and public aid allotments. Extra fees for the unrepentant morbidly obese that take up extra seats and contribute to excessive fuel consumption are completely in line concerning public transportation. No wide seats should be installed in any public or medical waiting rooms (e.g. doctors’ offices), let the recalcitrant obese stand and force them to think about their self-inflicted malady. Being fat and proud should have more than negative health consequences. Social ostracism as well as monetary penalties should be encouraged not discouraged as politically incorrect. Without actively enforced  punitive measures, the fat epidemic will continue to rise. Let us disabuse ourselves of any accommodation for the Fat Activists. Almost without exception, the unrepentant, obdurate  morbidly obese did it to themselves practicing three of the seven deadly sins, sloth,  gluttony and pride. (“The Fat Bastard Gazette” Vol.1 NO.6)

Dear readers, if you have read this far, the Captain would be most heartened if you would rate this and future articles and/or leave a comment at the top of the blog posts whether positive or negative. In this way, “The Fat Bastard Gazette” may better serve you and our entire readership.


Quinlan, C. H. (2014, September 2). Early Edition The Fat Bastard Gazette. Retrieved from The Fat Bastard Gazette: ‎https://thefatbastardgazette.wordpress.com/2014/09/02/early-edition

Ricciardelli, A. A. (2015, April 14). Shaping the online fat acceptance movement: talking about body image and beauty standards. doi:10.1080/09589236.2015.1028523

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot  Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.

OUR SCREAMING NEURONS AND WHY IT IS HARD TO DIET VOL. 1 NO. 33


agrpHaving trouble dieting? It may be due to negative feelings correlated with hunger making it hard to diet and lose weight. Hunger sensitive neurons in the brain may explain that problem.

Researchers, at the Howard Hughes Medical institute’s Janelia Research Campus, point to AGRP neurons as responsible for the negative feelings of hunger that make eating inevitable.

hunger_hormone-227x300The negative feelings correlated with hunger make it hard to diet and lose weight; these neurons lead to an explanation of that struggle, states Scott Sternson, a group leader at Janelia. In most settings where food is in abundance, AGRP’s message may seem counterproductive to dieting, but from an evolutionary point of view, it makes sense. For our ancestors, searching for food or water could mean moving into a hostile environment, which would require some internal override mechanism. “We suspect that what these neurons are doing is imposing a cost on not dealing with your physiological needs.”

AGRP neurons teach humans and animals to respond to sensory cues in indicating the presence of food. “We mouse eatingsuspect that these neurons are a very old motivational system to force an animal to satisfy its physiological needs. Part of the motivation for seeking food is to shut these neurons off,” says Sternson. Sternson and colleagues also showed that a different set of neurons specialized in unpleasant feelings of  thirst. These findings were reported in the journal Nature.

hunger“There was an early prediction that there would be neurons that make you feel bad when you were hungry or thirsty. This made sense from an intuitive point of view, but all of the neurons that had been looked at seemed to have the opposite effect,” he says. In previous studies, scientists discovered that neurons that encouraged eating did so by increasing positive feelings correlated with food.

“Some scientists had begun to suspect their ideas about a negative signal in the brain motivating hunger might be wrong. But their knowledge of the system was incomplete. AGRP neurons, located in a regulatory area of the brain known as the hypothalamus, were clearly involved in feeding behaviors: When the body lacks energy, AGRP neurons become active, and when AGRP neurons are active, animals eat. But no one had yet investigated those cells’ strategy for generating that motivation.”

Researcher Nicholas Betley and all conducted a series of behavioral experiments. They offered sated mice two flavored gels without any nutrient value. The mice sampled both flavors. The scientist turned on the AGRP neurons while they ate one of the two flavors. In the following tests, the mice avoided the flavor associated with the false hunger signal.

diagram of mouse brain
Click to enlarge image

Next, researcher Shengjin Xu used a tiny microscope to look inside the brains of the hungry mice and monitor the activities of AGRP neurons. “What came as a surprise,” Sternson says, “is that the AGRP neurons deactivated at the site of food—or even a signal that predicted food.”

“That wouldn’t make sense if the job of AGRP neurons was to make food taste better or if they directly controlled the individual actions that go into eating, which were two possibilities, Sternson says. But to encourage eating, a negative signal would need to turn off when an animal consumed food. So their imaging experiments further supported what they had learned in their previous experiments.”

So the next time you are trying to diet and you begin to feel those hunger pangs think about all those little AGRP cells that are crying out to be sated. That may be why it is so hard to diet when you are home next to the refrigerator or watching TV with all those food ads running one after the other. You can blame the AGRP cells for driving you to the brink of binge eating.

Dear readers, if you have read this far, the Captain would be most heartened if you would rate this and future articles and/or leave a comment at the top of the blog posts whether positive or negative. In this way, “The Fat Bastard Gazette” may better serve you and our entire readership.

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.

EXTRA EDITION “IS THERE A SIGNIFICANT DIFFERENCE AMONG DIFFERENT DIET PROGRAMS?” VOL. 1 NO. 32


Table 1 --- Diet Classes Based on Macro Nutrient Composition. Click to enlarge
Table 1 — Diet Classes Based on Macro Nutrient Composition. Click to enlarge

In an article published by JAMA (The Journal of the American Medical Association), it was found that overweight and obese adults lost a significant amount of weight with any low carbohydrate or low fat diet. The differences between the diets were statistically insignificant. Which diets are best remains undecided.

Table 2
Table 2 — Characteristics of Included Studies. Click to enlarge

The researchers did a meta-analysis as well as including 7286 individuals with a body mass index greater than or equal to 25. The largest weight-loss was correlated with low carbohydrate diets (8.73 kg/19.2lb. to 10.2kg/22.49lb.) and low fat diets (7.99 kg /17.6 lb. to 9.92kg/21.9lb) at six-month follow-up. As an example, the Atkins diet resulted in a 1.71 kg/3.77lb. greater weight-loss than the Zone diet six months follow up. However, the influence of behavioral support (3.23 kg/7.12 lb. to 4.23 kg/9.33 lb.) at 6-month follow-up vs (1.08 kg/2.38 lb. to 3.96 kg/8.73 lb.) at 12-month follow-up and exercise (0.64 kg/1.41 lb. to 1.66 kg /3.66lb.vs 2.13 kg /4.7 lb. to 3.85 kg/8.49 lb., respectively) on weight loss differed. This shows that while emotional support is important exercise achieved greater weight-loss one year out.

When the name diets were compared, all showed a weight-loss reduction compared to following no diet at all. Again all the weight-loss diets mentioned show statistically insignificant weight-loss differences but we will rank them nonetheless. These results are after a six months follow up:

Atkins diet 10.14 kg/22.35 lb.

Volumetrics diet 9.87 kg/21.8 lb.

Ornish diet 9.03 kg/19.9 lb.

According to the research, “All diets except Jenny Craig slightly decreased in their estimated effects at 12- follow-up compared with 6-month follow-up. The Ornish, Rosemary Conley, Jenny Craig, and Atkins diets were associated with the largest weight loss at this time point and all varied between 6.35 kg/14 lb. and 6.55 kg/14.4 lb.”

In summation, the study found that low carbohydrate and low fat diets were correlated with greater weight-loss than no dietary intervention one year out; “behavioral support and exercise enhance weight-loss.” Weight-loss differences were insignificant among all the different diets. Researchers recommend any diet one can “adhere to in order to lose weight.” Researchers did not study participants switching between diets, but offered such a strategy may increase better compliance with dieting in long run.

Dear readers, if you have read this far, the Captain would be most heartened if you would rate this and future articles and/or leave a comment at the top of the blog posts whether positive or negative. In this way, “The Fat Bastard Gazette” may better serve you and our entire readership.


Johnston BC, Kanters S, Bandayrel K, et al. Comparison of Weight Loss Among Named Diet Programs in Overweight and Obese Adults: A Meta-analysis. JAMA.2014;312(9):923-933. doi:10.1001/jama.2014.10397.

 

 

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot  Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.

 

THE NEW AND IMPROVED HOLY GRAIL OF WEIGHT-LOSS, OH MY, IT’S THE ‘THUNDER GOD VINE’! VOL. 1 NO. 31


An extract from the peeled root of the thunder god vine, Tripterygium wilfordii, used in traditional Chinese medicine, lowers food intake and causes up to a 45% decrease in body weight in obese mice. The active weight-loss compound is called Celastrol. Its potent mechanism of action sensitizes cells to an appetite-suppressing hormone called leptin. The research, entitled “Treatment of Obesity with Celastrol” published in “Cell,” is an indicator that a purified Celastrol compound could be developed into a drug for obesity.

Umut Ozcan
Umut Ozcan

Senior researcher Umut Ozcan, an endocrinologist at Boston children’s Hospital and Harvard Medical School states, “During the last two decades, there has been an enormous amount of effort to treat obesity by breaking down leptin resistance, but these efforts have failed. The message from this study is that there is still hope for making leptin work, and there is still hope for treating obesity. If Celastrol works in humans as it does in mice, it could be a powerful way to treat obesity and improve the health of many patients suffering from obesity and associated complications, such as heart disease, fatty liver, and type 2 diabetes.”

Click to enlarge
Click to enlarge

Leptin, a fat cell derived hormone, tells the brain that the body has enough food. Mice and people that lack leptin signaling eat huge quantities and become morbidly obese. Leptin does not reduce hunger or food intake in the obese regardless of high levels of leptin in the bloodstream.

Ozcan et al. found that Celastrol improved cell sensitivity to leptin in human cells. Obese mice reduced food intake approximately 80% compared to untreated obese mice. After three weeks of treatment, the mice lost 45% of their body weight by burning fat stores.

This impressive weight-loss exceeds the weight-loss produced by bariatric surgery. In addition, Celastrol lowered cholesterol levels and improved liver function and glucose metabolism. This translates into a lower risk for heart disease, fatty liver, and type 2 diabetes.

ChineseMedicine_web_1024“Even though Celastrol did not produce toxic effects in mice, Ozcan strongly urges caution for now because in-depth toxicology studies and controlled clinical trials are needed to demonstrate the compound’s safety in humans. “ Celastrol is found in the roots of the thunder god vine in small amounts, but the plant’s roots and flowers have many other compounds,” he says. “As a result, it could be dangerous for humans to consume thunder god vine extracts to lose weight.””

In future research, Ozcan et al. will investigate Celastrol at the molecular level. Moreover, how it improves leptin sensitivity producing weight-loss. “We have been heavily focusing on this line of research in my laboratory and hope that this approach will help us to understand the mechanisms in nature that are leading to the development of obesity,” Ozcan says. “In the end, my main goal is to see this research leading to a novel and powerful treatment for obesity in humans.”

Dear readers, if you have read this far, the Captain would be most heartened if you would rate this and future articles and/or leave a comment at the top of the blog posts whether positive or negative. In this way, “The Fat Bastard Gazette” may better serve you and our entire readership.


Cell, Liu et al. “Treatment of Obesity with Celastrol

DOI:10.1016/j.cell.2015.05.011

Cell Press

Press, C. (2015, May 22). “Thunder god vine used in traditional Chinese medicine is a potential obesity treatment.” Medical News Today. Retrieved from
http://www.medicalnewstoday.com/releases/294295.php.

 

 

Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon
Captain Hank Quinlan, Owner and Publisher, Chief Curmudgeon with Sam Borsalino, Assistant Publisher

Dear Hail-Fellows well met, “The Fat Bastard Gazette” is written and edited by your favorite curmudgeons Captain Hank Quinlan and

Flatfoot  Willie, Corespondent at Large with fellow Staff Writers
Flatfoot Willie, Correspondent at Large with fellow Staff Writers

Staff (monkeys in the back room). We offer an ongoing tirade to support or offend anyone of any large dimension, cultural background, religious affiliation, or color of skin. This gazette rails against an eclectic mix of circus ring ne’er do wells, big ring fatty and fatso whiners, congenital idiots, the usual motley assortment of the profoundly dumbfounded, and a favorite of intelligent men everywhere, the

May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .
May the Most Venerable H. L. Mencken bless our unworthy but earnest attempts at tongue in cheek jocularity .

“Great Booboisie.” Nor shall we ignore the wide assortment of shirkers, layabouts, and slugabeds.

Latest office staff confab at Fat Bastard HQ.
Latest office staff confab at Fat Bastard HQ.

All this and more always keeping our major focus on “Why so fat?”  Enough said? We at “The Fat Bastard Gazette” think so. If you like what you read, and you know whom you are, in this yellow blog, tell your friends. We would be elated with an ever-wider readership. We remain cordially yours, Captain Hank Quinlan and the Monkeys in the back room

“The Fat Bastard Gazette” does not purport to offer any definitive medical or pharmaceutical advice whatsoever in any explicit or implied manner. Always consult a qualified physician in all medical or pharmaceutical matters. “The Fat Bastard Gazette” is only the opinion of informed nonprofessionals for the general edification and entertainment of the greater public. 

No similarities to any existing names or characters are expressed or implied. We reserve the right to offend or support anybody, anything, or any sacred totem across the globe.